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Improving compliance with oral methotrexate guidelines

Improving compliance with oral methotrexate guidelines
Reference number
0279
Central Alert System (CAS) reference
NPSA/2006/13
Issue date01 June 2006
Action date (if applicable) (date field)31 January 2007
DH Gateway reference
6650
TypeAlert

This Patient Safety Alert reissues guidance to the NHS in England and Wales to reduce the risk of patient harm associated with the incorrect dosing frequency of oral methotrexate.

 

Oral methotrexate is a safe and effective medication if taken at the right dose and with appropriate monitoring. However, very occasionally problems with taking the medication can cause serious harm and even death.

 

Since July 2004 the National Reporting and Learning Service received 165 patient safety incidents reports involving oral methotrexate. Of these, 14 happened before the launch of patient safety alert (03) on 29 July 2004 and the remaining 151 happened afterwards.

 

Feedback from the Safety Alert Broadcast System (SABS) indicates that 18 per cent (104 out of 569) of NHS organisations in England have still not reported having fully implemented the actions set out in patient safety alert (03).

 

All NHS organisations should take steps to:

 

  • agree local action required;
  • provide patient information before and during treatment;
  • update prescribing and dispensing software programmes; and 
  • review purchasing.
Although the deadline for actions has passed, this guidance remains best practice. It should be followed to prevent future patient safety incidents.
Improving compliance with oral methotrexate guidelines - Patient Safety Alert
Improving compliance with oral methotrexate guidelines - Patient Safety Alert - 55 KB 0279 - Improving compliance with oral methotrexate guidelines - Patient Safety Alert - 2006-06-01 - V1
Making sure you take oral methotrexate safely- Patient Briefing
Making sure you take oral methotrexate safely- Patient Briefing - 28 KB 0278 - Making sure you take oral methotrexate safely- Patient Briefing - 2006-06-01 - V1
Making sure you take oral methotrexate safely - Patient Briefing
Making sure you take oral methotrexate safely - Patient Briefing - 36 KB 0278A - Making sure you take oral methotrexate safely - Patient Briefing - 2006-06-01 - V1 - CY
Oral methotrexate tablets - IT requirement specification
Oral methotrexate tablets - IT requirement specification - 422 KB 0279A - Oral methotrexate tablets - IT requirement specification - 2006-06 - V1
Oral methotrexate patient information leaflet & dosage record booklet
Oral methotrexate patient information leaflet & dosage record booklet - 111 KB 0267 - Oral methotrexate patient information leaflet & dosage record booklet - 2006 - V1
Towards the safer use of oral methotrexate
Towards the safer use of oral methotrexate - 1.32 MB 0102 - Towards the safer use of oral methotrexate - 2004 - V1